Allowing for an estimated 20% loss to follow-up, the final number of patients chosen per group was 220. A sample of 182 patients in each group (STEMI and NSTEMI/UA) would give a statistical power of 80%, with an alpha value of 0.05, delta value of 13%, 1:1 ratio of exposed: unexposed, and a confidence interval (CI) of 95%. This difference between the two studies allowed us to calculate the smaller sample size necessary to evaluate this outcome (i.e.
In RENASICA II, 15% of the patients had PCI and 17% developed left ventricular failure as an early complication. 2 Fifty percent of the patients in RENASCA 3 did not receive adequate treatment and only 8% underwent percutaneous coronary intervention (PCI) consequently, 30% of patients developed left ventricular dysfunction. A sample size with statistical significance was obtained using data from RENASCA 3 and RENASICA II.
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